Breakthrough in the active lifestyles market

With Lonza's award-winning UC-II® undenatured type II collagen1

Meet the needs of today's active consumers seeking proactive joint health and mobility support.

 

Discover what makes UC-II® the #1 undenatured type II collagen brand on the global market1

Fuel the new era of active lifestyle consumers with a different form of collagen 

Clinically-proven benefits

The most researched brand of undenatured type II collagen*

Low dose

Unsurpassed consumer convenience with just one small 40 mg daily dose2-5

Unique mechanism of action

Triggers the immune system to build joint cartilage6-8

Formulation innovation

Works across a wide range of in-demand dosage forms9

 

*as of January 2024

 
 

UC-II® undenatured type II collagen triggers the immune system to build joint cartilage6-8

Undenatured type II collagen's structure is uniquely preserved in the UC-II® ingredient using a patented, gentle processing method.

Epitopes are the bioactive regions that allow undenatured type II collagen to bind to the Peyer's Patches in the gut and induce the oral tolerance process.

The 3-dimensional shape of undenatured type II collagen preserves the bioactive regions called epitopes that induce the oral tolerance process.

Undenatured type II collagen is resistant to gastric acid and digestive enzymes, allowing it to retain the 3-dimensional shape and to preserve the epitopes.

 

 

UC-II® undenatured type II collagen makes daily pill compliance and repeat-purchase easy

Compared to other joint health ingredients, UC-II® undenatured type II collagen's small 40 mg dose makes daily pill compliance easy.

8 out of 10 consumers

say easy-to-swallow is important when making supplement purchasing decisions10

 

 

Watch our videos to learn more about the sustainability, sourcing, and discovery of UC-II® undenatured type II collagen

Discover the history and origins of UC-II® undenatured type II collagen

Learn about our sustainability, sourcing, and quality standards

Ready to keep up with the new era of active lifestyle consumers?

Download our eBook "Active, for life" to discover how your brand can innovate with the most researched brand of undenatured type II collagen*


 

Interested in more information on UC-II® undenatured type II collagen? 

 
  1. Fost and Sullivan, 2023. 

  2. Lugo JP, Saiyed ZM, Lane NE. (2016). Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study. Nutr J, 15(14). https://doi.org/10.1186/s12937-016-0130-8

  3. Lugo et al. (2013). Undenatured type II collagen (UC-II®) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers. J Int Soc Sports Nutr, 10(1), 48. https://doi.org/10.1186/1550-2783-10-48

  4. Schön et al (2022). UC-II Undenatured Type II Collagen for Knee Joint Flexibility: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Study. Journal of integrative and complementary medicine, 28(6), 540–548. https://doi. org/10.1089/jicm.2021.0365.

  5. Knaub et al. (2022). UC-II® undenatured type II collagen reduces knee joint discomfort and improves mobility in healthy subjects: a randomized, double-blind, placebo-controlled clinical study. J Clin Trials. 12(1):1000492.

  6. Bagi CM, Berryman ER, Teo S, Lane NE. (2017). Oral administration of undenatured native chicken type II collagen (UC-II) diminished deterioration of articular cartilage in a rat model of osteoarthritis (OA). Osteoarthritis Cartilage, 25(12), 2080-2090. https://doi.org/10.1016/j.joca.2017.08.013

  7. Yaremenko et al. (2021). Efficacy, tolerance and influence on cartilage metabolism of undenatured collagen type II UC-II (Mercana) in knee OA. PAIN, JOINTS, SPINE, 11(3), 5-12. doi: 616.718.56-001.056.

     

  8. Sahin et al. (2023). The effect of oral administration of undenatured type II collagen on monosodium iodoacetate-induced osteoarthritis in young and old rats. Scientific reports, 13(1), 6499. https://doi.org/10.1038/s41598-023-33763-2

     

  9. Pates, et al. (2023) UC-II(R) undenatured type II collagen data show retention during functional food and beverage prototype processing. Data in Brief, 48, 109216.

  10. Natural Marketing Institute. (2020). Supplements/OTC/Rx Trends US and Global Databases — U.S. and European data averages.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. This information – including product information – is intended only for residents of the United States. The product discussed herein may have different labeling in different countries. All information on this website corresponds to Lonza’s knowledge on the subject at the date of publication. Republication of this information or related statements is prohibited. All trademarks belong to Lonza or its affiliates or with authorization from third-party owners of such trademarks and are used here only for informational purposes. Copyrighted material has been produced with permissions or under license, all other materials.

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