Streamlined Selection of In Vivo Predictive Dissolution Media


Speaker: Deanna Mudie, Ph.D., Principal Scientist in Research and Development

Oral administration is the most common delivery method for medicines. If a patient is to get full benefit from an oral medicine, the solid dosage form must first dissolve in their gastrointestinal (GI) fluids, and then permeate across the GI membrane. The efficient development of robust oral drug products requires biopredictive in vitro dissolution methods that can evaluate how the interplay between the drug formulation and the properties of the GI fluid impacts on performance.
This webinar focuses on the design of dissolution media to support biopredictive dissolution testing, and highlights a method for selecting practical, physiologically relevant media based upon drug, formulation, and GI fluid properties.
Key learning objectives:
  • Learn how the interplay between drug, formulation, and gastrointestinal (GI) fluid properties impacts drug solubility and dissolution
  • Gain an insight into the range of dissolution media properties, and how they compare to in vivo GI fluid properties
  • Understand when a dissolution medium designed to save time, complexity and/or costs is expected to lead to physiologically meaningful in vitro dissolution testing, and when a more complex medium would be required.
Information in webinar to support learning objectives:
  • GI fluid and drug substance properties impacting dissolution
  • Range in dissolution media and GI fluid properties and compositions
  • Dissolution medium selection methodology based upon interplay between drug, formulation, and GI fluid properties
  • Amorphous dispersion case study – the impact of dissolution media on understanding in vivo performance

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