Join Lonza experts during a scientific program presentation and schedule a meeting to discuss your next project at our virtual booth. 

The 12th Global Drug Delivery & Formulation Summit will cover both small molecules and biologics, new technologies, concepts and case studies in areas such as formulation design for poorly soluble compounds; optimizing formulations for continuous manufacturing; and more. Learn more about the event here.
 
 
We hope you can join us for the following virtual presentation. Mark your calendar!
  
 

Program presentation

Aaron Stewart

Formulating amorphous solid dispersions: key challenges and considerations for a streamlined approach

Tuesday, March 16, 2021. 3:15 pm - 3:50 pm (CET / UTC +1)
 
Aaron Stewart, Associate Principal Scientist
 
About the presentation:

A large and increasing fraction of orally administered small molecules in pharma company pipelines have poor oral absorption due to low aqueous solubility or dissolution rate. To overcome these limitations, formulation approaches for increasing oral bioavailability are needed. Amorphous solid dispersions (ASDs) are a prevalent technology for addressing oral bioavailability challenges, given the applicability and scalability of the technology across a diverse compound physicochemical space.
 
Developing ASDs requires an integrated approach, where bioperformance, physical and chemical stability as well as manufacturability are all considered. Combining knowledge of key drug, polymer and gastrointestinal properties together with an in vitro and in silico toolkit is critical for achieving optimal in vivo performance while reducing development timelines and drug substance requirements.
 
This presentation covers some general strategies for developing a successful amorphous solid dispersion formulation, from formulation intermediates to final dosage forms.

 
  
 

Meet 1-2-1 with our expert in the virtual event: schedule a session.

 

 
Can’t attend the virtual event? Access other relevant technical content in our Knowledge Center:
  • Live webinar "Solid form screening and rational cocrystal design", watch now
  • On-demand webinar "Enabling streamlined formulation development of amorphous solid dispersion drug products", watch now
  • Whitepaper/executive summary "Solid form screening: a key drug development step", read now
  • 2020 AAPS PharmSci 360 presented posters and rapid-fires, see now
   



  
 

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