Particle Engineering For Inhalation Drug Delivery

Authors: Dr. Matthew Ferguson, Senior Principal Investigator

Inhalation-based drug products play a critical role in addressing the rising incidence of respiratory diseases around the globe. Particle engineered-based formulations are key in designing and developing effective dry powder inhaler (DPI)-based drugs.


This summary presents an overview of particle engineering technologies and a case study in which two engineering approaches are compared: spray drying (a “bottom-up” technology) and jet milling (a “top-down” technology). These two proven, scalable approaches are relatively simple and are often a good starting point to determine if a more complex technology is required for success.


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