Treating solid tumors with CAR-T cell therapy remains difficult, but with the advent of novel vector systems, such as transposons, coupled with tools like CRISPR/Cas9, researchers are making meaningful progress.
In this webinar, we examine how large-volume electroporation can support the reliable delivery of diverse clinically relevant cargo types, including DNA, mRNA, and CRISPR/Cas9 RNPs into large volumes of T cells using the 4D-Nucleofector
® LV Unit PRO.
Shigeki Yagyu, PhD (Shinshu University, Japan) and
Stefanie Muethel, PhD (Lonza, Germany) examine:
- How a large-volume electroporation platform for delivery of clinically relevant cargos for CAR-T development and GMP manufacturing allows for versatility in terms of process parameters, starting material, and cargo type
- How to achieve reliable, robust, and efficient delivery of different cargo types like DNA and mRNA to complex, clinically relevant cargos for CRISPR knock-out/ knock-in (RNPs) and transposon-based integration
- Why transposons are cost-effective and scalable non-viral gene editing solutions that provide safer integration profiles
Please fill out the form on the right. We hope you will enjoy the webinar!
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