Engineering approaches to respiratory drug delivery: Mannitol case study

Presented by Cameron Kadleck, Respiratory Scientist, Product Development, and Jimmy Beaty, Respiratory Scientist, Product Development

Both spray drying and jet milling are commercially viable engineering processes for the development of respirable drug products. This case study explores the material and performance properties of mannitol, spray-dried and jet-milled, for respiratory delivery. The head to head comparison reveals opportunities and risks for designing a product based on each approach.


Key Learning Objectives:

  • Understand the pros and cons of spray drying vs. jet milling 
  • Learn how to conduct a risk assessment to inform engineering technology selection
  • Explore how particle morphology influences aerodynamic performance

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